Long term studies tracking a high number of cases are still missing. For the time being known side effects are from the trials that were performed to get FDA approval, e.g.
LC Hurst et al. "Injectable Collagenase Clostridium Histolyticum for Dupuytren's Contracture" New England Journal of Medicine 361 (2009) p 968-979. abstract. "The most commonly reported adverse events were localized swelling, pain, bruising, pruritus, and transient regional lymph-node enlargement and tenderness. Three treatment-related serious adverse events were reported: two tendon ruptures and one case of complex regional pain syndrome. No significant changes in flexion or grip strength, no systemic allergic reactions, and no nerve injuries were observed."
Longer term side effects might include trigger finger symptoms and might occasionally require follow-up surgery Rozen_late_complications. Please note that concerns have been raised about this paper and the authors and publishers have withdrawn it. With this caveat we are still referring to it.
Page last modified: 12/30/2020