I wanted to tell you my story about when I was taking CoQ10. First let me apologize if this is a little long. I started taking this supplement for Migraines at a very low dosage around Feb 2008. It is also used frequently for woman who are perimenopausal and I have a brother-in-law who uses it for his diabetes.

My Dupuytrens started in July 2008, but I was not diagnosed until October. In December it started spreading to a second finger and then a third finger in January 2009. I have no known family history of Dupuytrens or family members and no other higher risk factors except for some little unsubstantiated blurb I've read about if you are being treated for epilepsy. I don't have epilepsy, but I take an anti-seizure medication used by epileptics as a preventative medication for my Migraines.

I recently changed doctors and went to a Migraine specialist who wanted to up the CoQ10. I asked her about what I had found on this site about CoQ10 and how it could inhibit the collagenase enzyme. This enzyme breaks down collagen - the molecule that makes up the Dupuytren's cords in the hands. She just told me to talk to my hand doctor before increasing or discontinuing the CoQ10. Here is Megan's post on CoQ10 on the site http://www.dupuytren-online.info/Forum_E...nase-0_353.html

After explaining everything to my hand doctor, the only real advice he could give to me was "if I were a family member, he would advise me not to waste my time or money on the supplement. That he hadn't heard anything good or bad about it." I decided to stop taking it.

After 1 month of stopping the low dose of CoQ10, I have to tell you I see such a remarkable improvement in my hand. I never had a contracture, but I had two small cords and a bigger nodule on my third finger. I only feel the one cord now and the one nodule which looks like it is still shrinking. There is still some dimpling on my palm, but it looks and feels much better than it did.

I just want to caution anyone with Dupuytren's and it's related disease's about taking CoQ10. I do realize it is not a cure, but if it can help, you really should be cautious about this supplement. It was helping my Migraines, but I am working on finding other things to help those. Thank you for listening and for all of your help.

I understand. I find so much about Dupuytren's fascinating too and there is a lot of good information on this site. It's also interesting that one of the Other Therapies for Duputren's is Collagenase injections as found in this article http://www.dupuytren-online.info/dupuytren_collagenase.html. If CoQ10 inhibits the natural production of collagenase, then that can't be good for us.

I am also still taking my anti-seizure medication and have seen this improvement to my palm in this short of a time. It is kind of a shame because I have only heard good things about CoQ10 until I found this, but I would rather not take it now. This definitely appears to have been a downside of CoQ10 for me.

Let us know how it works out. Correlation might be interesting.
Wolfgang

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I have been taking Coq10 for several years which has coincided with with an increase in severity of my Dupuytren's. I had NA six months ago with little success and my hand is almost as bad as it was prior to NA. I am going to stop taking Coq10 and see if things improve.

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It has been almost another month since I have been off of CoQ10 and I thought I would report in again. I can feel the one cord when I press down on my palm and I still have the one nodule. It did shrink a little more and it does not hurt any more.

I'd like to know if anyone else who stops the CoQ10 finds a change in as well.

I just finished reading about Q10 and decided i'm going to quit taking it. Please tell me that all of you are still having good luck by not taking Q10. Take care