I've read that DC rarely affects the index finger. Has anyone had it in the web between the thumb and index finger? I had a rapidly growing nodule there removed along with a cord along my index finger's tendon.

Hi Australia calling.Unfortunatelly I have DD on both hands on thumb and index finger. I also have a small graft on the base of right thumb and a large graft between the base of left thumb to the index finger .In the past l8 months I've had three small operations performed on the right thumb along previous scar lines as they became raised and very painfull. I always wear cotton type rubber faced gloves to do any work to protect this area.I have had work performed by two plastic surgeons and both advised not to allow the contraction to exceed 5-6 cms(2inches ) before operating. I have full use of both hands but I do stretching excercise every day.I am now 65yr and was diagnosed at 35 yr but did not have surgery for l5 yrs or so. I was told I had the disease in an aggressive form and surgery will be ongoing. I now have much smaller operations ( day surgery)and within 14 days I am back to so called normal . I would be hopeful that AA4500 Collagen won't be too far off I 've recently read Auxillium Pharmaceuticals sponsored by BioSpecifics Technologies Corp. is carrying out its second Phase 3 trials on 200 patients at 15 locations in US and with 60 patients in Australia and Switzerland. I think you may now have more options open to you.

I think the idea that Dupuytren's rarely affects the thumb or index finger is just more misinformation that's been endlessly repeated and has even found its way into clinical literature. Both my thumbs and index fingers have contractures. I've already had surgery on one of the fingers. I currently have a large and progressive contracture in the "web" of one thumb - I keep fighting against it with stretching.

I have DC in my left index finger and thumb (along with a few other nodules on my left palm).
Incidentally I had surgery on my right hand five weeks ago. My DC was very aggressive (right pinkie straight to folded almost completely in 6 months) and so I don't think that I had any other option available (I made a few enquiries about alternatives from info on this site but I live in a "backwater" as far as advanced surgical techniques are concerned! (Swansea, South Wales, UK). Excellent surgeon (Mr Newington) got my finger 90% straight. After an initial setback of an infection, the wound has healed and although I still do not have full mobility, played my first game of golf today. With physio/splinting I hope to have full use soon.
I have a follow-up consultancy on 13th August, where I'll be discussing options for my left hand - I'll report back any useful info here.
For what it's worth, I agree completely with other posters on here that the aggression of DC is related to percussive impact. Nodules on the undersides of both feet appeared at the age of 31 (I played football since 14) and my hands started deteriorating rapidly at 40, 4 years after I started playing golf! ALL the nodules/cords on my hands are/were directly where a golf club sits in my grip! I'm 44 now (male).

I have agressive DC and my hands have never sustained any unusual impact or trauma.