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Could Gadolinium (MRI contrast agent) accelerate Dupuytren's?
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12/27/2023 21:58
jmaineri 
12/27/2023 21:58
jmaineri 
Could Gadolinium (MRI contrast agent) accelerate Dupuytren's?

Wondering if there any docs / medical folks on this forum who can help me understand if there might be any potential relationship between Gadolinium (MRI contrast agent) and Dupuytrens?

I am having an MRI, possibly with contrast (Gadolinium.) One of the (rare) side effects of Gadolinium is a type of systemic fibrosis (NSF). Reading about this caused me to wonder if Gadolinium could potentially accelerate Dupuytren's? While I realize these are different conditions, both are types of fibrosis as I understand it. Is this a reasonable concern / extrapolation? I included 2 links below which have me thoroughly confused :-).

Thanks for any input.

p.s. I realize that NSF is a rare side effect and that it may be that the need for detailed imaging trumps the potentially rare side effects of Gadolinium. I'm not there yet. I am just wanting to know if the underlying mechanism could impact/accelerate Dupuytren's.

https://pubs.rsna.org/doi/full/10.1148/rg.2020190110
..Involvement of periarticular tissue can result in irreversible contractures, with one study reporting this finding in 10 of 22 patients (45%).....Biopsy results often reveal the presence of bland dermal spindle cells, epithelioid cells, and thickened collagen bundles with surrounding clefts,...Other skin findings include the presence of “cobblestoning,” wherein raised papules develop over a region of induration...

https://www.sciencedirect.com/science/ar...022202X15360565

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Dupuytren   Gadolinium   sciencedirect   reasonable   extrapolation   underlying   periarticular   irreversible   relationship   Involvement   accelerate   understand   “cobblestoning   potentially   surrounding   thoroughly   022202X15360565   epithelioid   contractures   2020190110