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10/20/2013 17:51
spanishbuddha  Administrator
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10/20/2013 17:51
spanishbuddha Administrator
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Re: Duration of RT working after last treatment
I would wait. Give time for healing from the RT and procedure you have had done. Take some extra care of your feet with help from chiropodist or podiatrist. As nan says don't beat your self up, what's done is done, move on, perhaps the outcome will still be good. Only think about other options in, say, six months if things are worsening. Best wishes.
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10/20/2013 17:56
Jolene 
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10/20/2013 17:56
Jolene
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Re: Duration of RT working after last treatment
Thank you. I go back Dec. 16th. Which is week 14 (3 months & 1 week) after the last round of RT on that foot.
I thought I read some place that prof. S has done 3 round in certain cases.
Have you read this any place?
Edited 10/20/13 21:00
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10/20/2013 18:02
spanishbuddha Administrator
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10/20/2013 18:02
spanishbuddha Administrator
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Re: Duration of RT working after last treatment
Yes, ProfS will do a third round in some circumstances. He offered it to me on a small area of one hand this August, after an examination, but I am going to wait. So it is possible, but I don't know how long you would have to wait, to allow full recovery or observation of the effects, or the precise circumstances, such that a third round will be considered. In my case, it is two years since the previous treatment.
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10/20/2013 18:05
Jolene
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10/20/2013 18:05
Jolene
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Re: Duration of RT working after last treatment
Do you know of anyone that had round 3 after 3 months?
I my I am so screwed.
Edited 10/20/13 21:05
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10/20/2013 18:14
spanishbuddha Administrator
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10/20/2013 18:14
spanishbuddha Administrator
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Re: Duration of RT working after last treatment
I don't know of anyone who has had a third round. I would think after 3 months is too soon. Maybe you just have an isolated flare that will settle down anyway. People have reported a modest worsening of symptoms after RT anyway, I expericed this myself, before it settles down after 6-18 months.
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10/20/2013 18:42
ell 
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10/20/2013 18:42
ell
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Re: Duration of RT working after last treatment
My radiologist oncologist said absolutely radiation can be done again - but not until at least 12 months have passed. He also said that RT can continue to work on radiated tissue for 12-18 months after treatment. No, it will not work on tissue that was not present during treatment, but if you just finished 5 weeks those 'new' nodules could have already there, just too small to feel. I would not panic, but I would not do any other procedures that may traumatize existing nodules - just based on the knowledge that this can cause DD to excelerate.
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10/20/2013 19:44
Jolene
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10/20/2013 19:44
Jolene
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Re: Duration of RT working after last treatment
I wish that was the case, The new nodules already there. Only I know its not because I had MRI right before round 2 of RT. The MRI showed only the original two and they had shrank some from round one of RT.
If perhaps the vibrating tool the Chiro used on the bottom of the foot broke some of the original nodules up, and these 2 new ones are part of the old ones is there a chance the radiation will work on then?
O I am simply beside myself.
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10/20/2013 21:08
ell
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10/20/2013 21:08
ell
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Re: Duration of RT working after last treatment
Jolene, I'll echo what the others said about giving yourself a break. This disease has made us all desperate at one time or another. If in fact the nodules are pieces of one that was irradiated then the RT should certainly continue to do it's work. And if you want to get retreated after a year and your current doctor won't treat you, call Dr. Crimaldi in NC. He's on the list on this site.
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10/21/2013 16:21
JohnG 
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10/21/2013 16:21
JohnG
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Re: Duration of RT working after last treatment
While the radiation leaves your body almost immediately, the biological response is slower. I think the biological response is not completely understood, so it's not known for sure how slow it is. But I'd bet that it's finished much faster than in 5 weeks.
Here is a thread on this:
http://www.dupuytren-online.info/Forum_E...-rt-0_1455.html
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10/31/2013 22:15
stephenp
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10/31/2013 22:15
stephenp
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Re: Duration of RT working after last treatment
For DD and hands, the therapeutic effect can continue (in my case) for many months (6-12?) after the last treatment with nodules shrinking, getting softer and flatter. I have thought about this a lot in terms of collagen breakdown. There is some literature that suggests that the half life of collagen is on the order of 100yrs! I understand how RT can halt progression by killing the active cells that are causing the problem. This is reflected in the need for RT when the disease is active.
I do not understand how RT stimulates collagen breakdown. It would seem possible that RT activates cells such as macrophages that secrete collaginases that will breakdown collagen. However there are not many macrophages in skin. More likely, perhaps RT kills "feral" disease causing fibroblasts and new fibroblasts migrate into treated tissue and these cells secret collaginase that breaks down collagen in the tissue.
Still lots of unknowns in this disease.
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