| recurrence--why after NA or collagenase |
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09/13/2009 09:08
guestnot registered
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09/13/2009 09:08
guestnot registered
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recurrence--why after NA or collagenase
Can someone help me with this one?
I don't really understand the mechanics of recurrence after NA or collagenase. After the cord is cut through or snapped I'm wondering how recurrence happens--possibly the following:
1. new cord is formed
2. cut or snapped cord reconnects
3. something else that I don't know
I'd be grateful for any answer to this.
Thank you
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09/13/2009 23:10
callie 
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09/13/2009 23:10
callie
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Re: recurrence--why after NA or collagenase
The recurrence occurs because there is still diseased tissue in the hand after NA. Growth resumes. I had surgery ( limited fasciectomy) over seven years ago and have had no signs of recurrence. The microsurgery on my hand removed most/all of the diseased tissue. However, Dupuytren's can/could start again some time just as in the past. A fasciotomy is functionally the same as NA and has a greater chance for recurrence than a fasciectomy.
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09/14/2009 02:08
flojo
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09/14/2009 02:08
flojo
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Re: recurrence--why after NA or collagenase
I had radiation therapy, RT, (see left side menu) to stop the progression of Dupuytren's. It helped reduce nodules and lessen tightness. It does not release cords that are already developed. I am convinced that it has worked for me in stopped the progression of this blasted disease.
Flora
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09/14/2009 07:35
guestnot registered
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09/14/2009 07:35
guestnot registered
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Re: recurrence--why after NA or collagenase
Still not so clear--it seems that from what Callie says, that an entirely new cord forms after the cutting/snapping of the "old" cord with NA or with collagenase. I'd be grateful if someone who has had NA and then a recurrence comment on this.
To Flojo (whose many entries I've enjoyed), yes, I understand the benefits of RT, but that is different than NA or what I'm asking. Thanks anyway.
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09/14/2009 19:06
flojo
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09/14/2009 19:06
flojo
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Re: recurrence--why after NA or collagenase
Yes, the disease remains in the hand after NA and is still growing. NA only releases the cords. I had NA to release about 5 cords before I had RT. The nodules and cords continued to form after I had NA during the 3 months before I had RT.
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09/15/2009 01:02
moondanc
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09/15/2009 01:02
moondanc
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Re: recurrence--why after NA or collagenase
Quote:
Still not so clear--it seems that from what Callie says, that an entirely new cord forms after the cutting/snapping of the "old" cord with NA or with collagenase. I'd be grateful if someone who has had NA and then a recurrence comment on this.
To Flojo (whose many entries I've enjoyed), yes, I understand the benefits of RT, but that is different than NA or what I'm asking. Thanks anyway.
Hi there,
I wish I weren't qualified to answer this but, sigh, I am. I've had NA twice and collagenase once. The first NA--MCP joint, right finger, right hand- lasted around 2 years. The cord either "rejoined" or developed along side because it was the same finger, same joint that was affected. Then I had collagenase (in a trial), the cord broke but because the trial only allowed three different injection sites, lots of cord remained although my finger did straighten for about a year. All the lumps and skin tethering remained in my palm and on the sides of my fingers after Xiaflex. After Xiaflex, DD progressed in that finger to the PIP joint-- in little over a year-- and I just had NA again-- it worked to release the finger but has already started to contract again. After Xiaflex, I got DD something fierce in my left hand-- none of the fingers in my left hand had contractures severe enough-- or in most cases at all--to qualify for the trial. I'm beginning to think it's not just a coincidence that my disease got aggressive after Xiaflex and I sure wish there were
some long term followup studies on Xiaflex to know how long it lasts, whether subjects had more aggressive recurrences, etc.
HTH,
Diane
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