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Xiaflex today
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08/14/2010 17:51
flojo 
08/14/2010 17:51
flojo 
Re: Xiaflex today

Phillip and Dave,

i didn't pick up your age. if you are young, i know that the discussion with you would include your age and other factors. 1% seems minimal to me, but then, I'm 72 and actually believe the risk is almost nil. There are all the disclaimers about every medication taken, but we either decide the benefits outweigh the risks/side effects or not. For me, the benefit of stopping the progression of my DD was worth the risk.

What bothered me more was the % of chance that RT might not work to stop the progression. That would really be a bummer. RT is not 100%, but there is a greater chance than not that it will be effective if Dups is active when RT is administered. It was critical to Dr. T to hear my symptoms that indicated active Dups. My symptoms did indicate active Dups, or Dr. T would not have done it.

08/14/2010 18:16
LubaM. 
08/14/2010 18:16
LubaM. 
Re: Xiaflex today

flojo:
Phillip and Dave,

i didn't pick up your age. if you are young, i know that the discussion with you would include your age and other factors. 1% seems minimal to me, but then, I'm 72 and actually believe the risk is almost nil. There are all the disclaimers about every medication taken, but we either decide the benefits outweigh the risks/side effects or not. For me, the benefit of stopping the progression of my DD was worth the risk.

What bothered me more was the % of chance that RT might not work to stop the progression. That would really be a bummer. RT is not 100%, but there is a greater chance than not that it will be effective if Dups is active when RT is administered. It was critical to Dr. T to hear my symptoms that indicated active Dups. My symptoms did indicate active Dups, or Dr. T would not have done it.
Like Flojo, I had RT with Dr. T. for my left hand Nov. 2009. I am 67 and for me the 1% risk after 25 yrs. seemed minimal as well.

Also my decision to radiate left land was based on the fact that I had a recurring contracture of small finger at PIP and DIP joints, on my right hand, necessitating a repeat NA after four years, and I wanted to try catch the disease in my left hand before any contractures occured.

08/15/2010 08:30
wach 

Administrator

08/15/2010 08:30
wach 

Administrator

Radiation risk

I believe that 1 % risk of cancer due to radiation therapy is a very pessimistic estimate. Of course, the risk is age depending but current estimates are rather in the .02 - 0.2 percent range http://www.dupuytren-online.de/downloads...20Dupuytren.htm, depending on age.

Wolfgang

08/15/2010 15:22
PhilipHa1 
08/15/2010 15:22
PhilipHa1 
Re: Radiotherapy risk

Flojo,

I was 34 at the time of my RT treatment, 46 now. As I said in my previous post if I had been quoted 1% at the time of my treatment I would have thought more about the treatment, whereas 0.1% is a much easier decision as it is not significant compared with your lifetime ~25% risk of cancer. I also only had 5 x 3GY, didn't go back for a second course of treatment, so my risk is even lower. My guess is 1% is far too high and probably incorrect, otherwise we would have seen a few example cases of secondary tumours as a result of the treatment, to date there have been none and I suspect there have been 1,000s of treatments over the years.

Philip

08/15/2010 18:22
lori 
08/15/2010 18:22
lori 
Re: Xiaflex today

I was 53-54 when I started my first RT. I will be turning 55 next month. As I told Flora, I did not blink at the low risk rate for RT. The painful consequences of allowing my finger to contract overshadowed the miminal risk of cancer. Since my Dups was active the RT worked and hopefully will continue to work. I will have it again if my DD reactivates. I figure I am exposed to more cancer causing enviromental issues (food, wine, water, etc.. and the ones I know nothing about) than the little bit of radiation I had on my palm. I had to put into prospective the desired outcome vs the miminal risk of cancer. Looking at it that way, for me there was no debate. Not to say, I wasn't nervous, because I was. I am more leary about the Xiaflex injections and the unknown long term effects than any jitters the RT caused. I admire those of you who have had the Xiaflex injections, you are pioneers just as Wolfgang and others were pioneers for RT and NA many years ago. Without those of you stepping up to the plate, (be it Xiaflex or NA) we would all be stuck with hurting hands, fingers and lives just waiting till our hands were devastated enough to have surgery.


Thanks to all of you,

Lori

08/16/2010 13:53
flojo 
08/16/2010 13:53
flojo 
Re: Xiaflex today

Wolfgang, I had not found the article that you linked. I like those numbers even better!

If I ever got it, I don't know that I could attribute cancer on my hand to RT anyway because I have had early detected skin cancer elsewhere anyway - basal cell and squamous cell. Goes with the Northern European heritage like Dupuytren's. I watch for skin cancer like a hawk, too.

I'll temper the way I refer to the risks of RT. Even though about or less than 1% risk is of little or no concern to me, I want to be more accurate.

08/16/2010 14:56
wach 

Administrator

08/16/2010 14:56
wach 

Administrator

Re: Xiaflex today

Flora, sorry about that! Doesn't the link work on your computer? It does work on mine.

Wolfgang

flojo:
Wolfgang, I had not found the article that you linked. I like those numbers even better!

If I ever got it, I don't know that I could attribute cancer on my hand to RT anyway because I have had early detected skin cancer elsewhere anyway - basal cell and squamous cell. Goes with the Northern European heritage like Dupuytren's. I watch for skin cancer like a hawk, too.

I'll temper the way I refer to the risks of RT. Even though about or less than 1% risk is of little or no concern to me, I want to be more accurate.

08/16/2010 15:09
Larry 
08/16/2010 15:09
Larry 
Radiogenic Risks - Carcinogenesis

wach:
Flora, sorry about that! Doesn't the link work on your computer? It does work on mine.

Wolfgang
flojo:
Wolfgang, I had not found the article that you linked. I like those numbers even better!

If I ever got it, I don't know that I could attribute cancer on my hand to RT anyway because I have had early detected skin cancer elsewhere anyway - basal cell and squamous cell. Goes with the Northern European heritage like Dupuytren's. I watch for skin cancer like a hawk, too.

I'll temper the way I refer to the risks of RT. Even though about or less than 1% risk is of little or no concern to me, I want to be more accurate.



There is an abstract available on the topic of carcinogenesis = induction of cancer by iomnizing radiation !

THis is a paper written in 2005 by Prof. Seegenschmiedt and a group from Delft (Netherlands) entitled :

Estimation of the carcinogenic risk of radiotherapy of benign diseases from shoulder to heel.


Jansen JT, Broerse JJ, Zoetelief J, Klein C, Seegenschmiedt HM.

Radiother Oncol. 2005 Sep;76(3):270-7.PMID: 16157402 [PubMed]


.... for radiation dose exposure its stated less than 1% or ask Prof. Seegenschmiedt in Hamburg

08/17/2010 04:20
flojo 
08/17/2010 04:20
flojo 
Re: Xiaflex today

Wolfgang,
Yes, the link does work. I just had not run across it before.

08/19/2010 14:59
Jill 
08/19/2010 14:59
Jill 
Re: Xiaflex today

Eric, it's been another five days now since you posted, how's it going with the Xiaflex finger?

-Jill


www.dupuytrenscenter.com

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progression   Xiaflex   manipulation   injection   circumstances   radiotherapy   radiation   personal   treatment   post-procedure   treatments   also-depending   quantification   Wolfgang   Seegenschmiedt   Carcinogenesis   straightforward   dupuytren-online   straightening   dupuytrenscenter