Basically correct. With nodules you might also consider injection of cortizone. e.g. Kenalog (link: http://www.dupuytren-online.info/dupuytren_steroids.html ).

Wolfgang

I watched all the videos on Youtube of the lady who had the enzyme injections and manipulation...very interesting, but the pain she describes sounds excruciating to the point that she is not sure that she'll go for the third injection.

Question: Is this the Auxillium Trial Phase III Injection that we are all anxiously awaiting to come out in 2009-2010?

I had NA two years ago (which was successfull, but it came back to pre-NA contracture within the year....and I will probably have to re-do it)...but at least...it wasn't painful like she describes it.

Are there others who have had the injections without suffering such pain? I would rather re-do the NA than go through what she is describing.

"It's so much better than it was that I would say.... 'fine'".

Not a ringing endorsement, but this was only one person's experience with an MCP. Release of the PIP is the gold standard in my view. We have few people who have had both NA and Collegenase so far.

Unfortunately we will never see is a trial of Collegenase Vs NA. The expense would prohibit that because who would put up the money? Who would have anything to gain? Certainly not the holders of the Collegenase patent. It's *so* much more expensive than NA it would have to blow NA away to be of benefit. Most of us know by now that is not going to happen.

It's still too soon to know the exact advantages of Collegenase, but so far I'm not impressed. Either way, I'd still exhaust these two alternatives before resorting to full Open Surgery. That is the entire reason millions are being spent to bring Collegenase to market. In other words, millions are being invested on the premise that both patient and surgeons desperately want an alternative to OS. The thing is, we already have one. NA is so *amazingly* under estimated.

Edited at 08/22/08 08:12

As I learned more about what kinds of treatments would be available, it became clear that I was too young to get NA every two-three years when surgery would remove (most) of the diseased tissue and is less likely to return to the same spot.

Yet with NA, I would have to have the same procedure repeated for the next 30+ years on the same finger to say nothing of the new cord growing under my other palm. Argh, I hate repeating the same task over and over and over for such an extended period.

It took 10 years to have it progress to the point I had to have something done. No way was I going to start down the path of such regular treatments that only treats the symptom without removing the diseased tissue so the cord reconnects and contracts again.

NA was not for me.