Marco2045:

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Well, curcumin reduces tnf-alpha and tgf-beta1, both of which are responsible for Dupuytren's progression. Of course, it is necessary to see how much it reduces them in Dupuytren's nodules and how much it slows down the accumulation of lymphocytes and the multiplication of myofibroblasts in the diseased part. However, it is true that, compared to the past, the absorption of curcumin and its permanence in the blood have greatly increased in recent years (for example NOVASOL). Therefore, it is not surprising that in the past, even in the recent past, curcumin has served no purpose for Dupuytren. But maybe today it's not like that anymore! I would also like to try a transdermal cream based on curcumin incorporated in liposomes or nanosomes ... maybe it stops or reduces the progression of the disease!