Anyone else know of any other groups/companies working on CTGF inhibitors? |
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08/10/2004 23:08
Quinnnot registered
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08/10/2004 23:08
Quinnnot registered
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Anyone else know of any other groups/companies working on CTGF inhibitors?
http://www.fibrogen.com
From the FibroGen site:
Connective Tissue Growth Factor (CTGF)
What is CTGF? Connective tissue growth factor is a fibrogenic cytokine, a growth factor that is required for the fibrotic response mechanism in tissues. CTGF is key to the maintenance of persistent fibrosis and scarring and is an important target in FibroGen's anti-fibrotic drug discovery efforts.
CTGF functions as an autocrine growth factor, which means that it acts on the same cells that produce it, causing the cells (fibroblasts) to proliferate, differentiate and produce more collagen.
FibroGen is developing monoclonal antibodies and small molecules that block the activity of the intact CTGF molecule, as well as its fragments, at critical steps during the fibrotic cascade, including:
*CTGF signaling *CTGF receptor activation *TGF-beta stimulation of CTGF gene induction *Proteolytic processing of CTGF
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08/10/2004 23:54
Stevenot registered
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08/10/2004 23:54
Stevenot registered
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Great detective work...
It looks like their lead compound that inhibits CTGF has complete a Phase I study for safety and tolerability. It is an injectible drug and they say may have uses in many fibrotic conditions including dupuytrens disease. Looks like this would be the long term cure for the disease we'd all love to have if it works. But right now they probably have higher priority indications like Pulmonary Fibrosis, etc. to work on so it may be a while. But if a drug gets on the market, a doctor can use it for anything they want. This is something we should all keep an eye on.
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08/11/2004 23:08
Ian Widernot registered
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08/11/2004 23:08
Ian Widernot registered
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Steves
Steve Bopp, Stephen Babka, Steve, all in a 24 hour period breaking news. Probably, it is nothing. Only sceptics notice such distractions. So, Steves, what are your points? Do you have a "miracle" to offer? Who produces your miracle? Thank you.
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08/11/2004 23:39
Stevenot registered
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08/11/2004 23:39
Stevenot registered
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I am not the same as Steve Bopp, etc...
Go to their website yourself. I didn't call it a miracle cure, but it is a compound in clinical trials (FG-3019) that you can see for yourself (clinicaltrials.gov). The patents filed on it also specifically address Dupuytrens. I don't know any other compound that could prevent growth of Dupuytrens other than this that is in trials as most of the research has only been basic science. Don't expect something this year or even maybe 5 years from now, but with a long life ahead of me I'm glad to hear something is being done that could represent a cure not a temporary fix like NA, collagenase, etc.
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