Stage 1:

My hope is that Collagenase will create the perfect One-Two Punch along with NA to treat *all* manifestations of Dups without surgery until something more like a "cure" can be discovered. NA is not at it's best with PIP contractions and not so effective when there are no discernible cords. Lets hope that Collagenase, as a biochemical dissolver of Dups tissue, can fill in the gaps left by NA. Surgery, then, can be delayed indefinitely for most in hope for the long awaited Magic Bullet.

Thanks jim h

This is very disconcerting......and looks quite true. A post from Auxilium's web site:

"AA4500 is an enzyme that was granted orphan drug status by the FDA. It is injected into the affected area in an outpatient procedure to soften and reduce the size of the scar tissue and straighten the curvature of the penis."

See: http://www.auxilium.com/pipeline_peyronies.html

No mention of the use of AA4500 for Dupuytrens. If they were planing to move forward with the treatment for Dupuytren's, you'd think they would mention it. BioSpecifics hasn't updated their website in years. When they finally do, there will be no economic reason to continue this Forum. With the French Forum hacked out of existence there will no place on the Net for a continued open discussion among Dupuytren's sufferers. *Folks, this is not good.* If it were not for This Forum, very very few of us would have heard of NA, and this includes Eaton himself (who would not now be doing NA).

We don't have a backup system for the day that some accountant discovers that BioSpecifics is now wasting it's money. Perhaps those at BioSpecifics will realize how valuable this site has been and spear it, but I doubt it. Right now I'd say that our best bet would be for Eaton to add a Forum to *his* site. Hopefully someone who is going to be seeing him soon might suggest to him that hosting a new Forum might be a good idea right about now.

Maybe someone can start the yahoo message board NOW. There would then be two parallel forums which would collectively get more postings and more people, new people.Then if this forum was discontinued there would be another forum up and running. Nothing is worse than when a forum suddenly stops and the members have no idea where to go.

Has anyone actually downloaded/read this study? It can be downloaded from this link:

http://www.wstagner.com/dlinks.htm

I'd like to see a thread started in this forum by READERS of the definitive paper written by the colleganase originators.

Jim,

Was that completion of just *one* of the required sites or *all* of the sites. I think the design of the study calls for 3 or 4 sites. They must *all* be completed. This is *Great* news. The more choices of procedures available the better! Soon, I may qualify for someone's definition as a "Collagenase Ringer" ! :)