Genetic information |
|
1 2
|
1 2
|
07/18/2003 23:43
Stevenot registered
|
07/18/2003 23:43
Stevenot registered
|
Genetic information
Does anyone know if studies have been/are being done that determine the genetic cause of Dupuytren's, Garrods Pads, Peronie's, and Ledderhose? I'm interested in finding the physiological cause(s) of these diseases with hopes that cures can then be found. I've read posts on this board for months now and it seems there are pros/cons for different approaches to dealing with the inflictions and the debate over individual strategies will go on ad nauseum until a cure is found. Is anyone aware of any study/studies that will determine the genetic cause(s) of these maladies. Thanks. Steve
|
|
|
07/18/2003 23:52
Anon Emusnot registered
|
07/18/2003 23:52
Anon Emusnot registered
|
Genetic information
It might help if you posted your E-mail address.
|
|
|
07/20/2003 23:28
Briannot registered
|
07/20/2003 23:28
Briannot registered
|
Genetic information
The June 03 issue of Plastic Reconstructive Surgery has an abstract of work by Bayat, Watson, et al suggesting that TGF-beta 1 is involved and that gene zf9 may be of interest. The abstract also states that as yet no specific gene has been identified. On a simpler level, web sites state that DD is caused by an autosomal dominant gene with variable penetration; that means that if one parent has the gene, 25% of offspring may likely acquire it. If both parents have the gene, 50% of offspring are likely to get it. (likely, not inevitably.) Not all carriers will have noticeable symptoms that result in a diagnosis. If you are interested in the Bayat article it is at NCBI Pub Med. A search for Dupuytrens genetics should produce links. I was not sure how specific an answer you want; I hope this is of some interest. Basically DD may be a normal healing process that has gone haywire and fibroblast cells over-prolifirate in palm tissue due to DNA in those cells. The abstract provides a bit more detail. NA severs the collagen fibers; Collagenase "dissolves" the collagen fibers. Surgery removes the overgrown tissue. Skin grafts replace "haywire" tissue. Eventually gene therapy may be available. That is the limit of my understanding; I hope that it is fairly accurate. Someone correct me if not.
|
|
|
07/20/2003 23:26
JohnWnot registered
|
07/20/2003 23:26
JohnWnot registered
|
TGF
So this Transforming Growth Factor is like a CIF (cartilage inducing factor)?
|
|
|
07/20/2003 23:04
JIMnot registered
|
07/20/2003 23:04
JIMnot registered
|
Cartlidge Factor
For years, I have had bad knees (cartlidge) and rather than go the surgery route, I adjusted my life style to a non running and rather inactive one. I have always thought there was some connection to cartlidge. The body is such an efficient healing machine, perhaps it triggers (genetically) an onslaught of collagen generation to compensate for the deficiency, and finds its way to the hands and feet extremities and settles here where the blood vessels are the smallest. This overproduction, coupled with intakes of glcosamine chondroitin and even vitamin C adds to the condition. It could be a gene gone haywire or one which gets "turned on" to correct a problem. Anyone else had orthopedic problems prior to DC. JIM
|
|
|
07/20/2003 23:11
JERRY
|
07/20/2003 23:11
JERRY
|
DNA
Many of us have.
|
|
|
07/20/2003 23:18
Sean,not registered
|
07/20/2003 23:18
Sean,not registered
|
DNA
Jim, Your reasoning could have some merit, but I have had no physical problems whatsoever, except Dupuytren's and Ledderhose. I think it is just strong genetics that determines severity and who gets it.
|
|
|
07/21/2003 23:57
JohnWnot registered
|
07/21/2003 23:57
JohnWnot registered
|
DC
Sean/Gary: you are not spokesman, the test case, nor the 'model' for dupuytrens.
|
|
|
07/21/2003 23:46
jim hnot registered
|
07/21/2003 23:46
jim hnot registered
|
Thanks
I have no significant physical problems either, other than Dupuytren's. My general health is good and I take no medications. No serious injuries in my past, no trauma to hands or feet. So I'm dubious of any attempts to make a strong correlation between Dupuytren's and any factors other than genetics.
As with many medical problems, Dupuytren's might turn out to have multiple root causes. We just don't know, yet.
|
|
|
07/21/2003 23:33
Stevenot registered
|
07/21/2003 23:33
Stevenot registered
|
Thanks
Thanks for those who posted to my original inquiry about a DNA link. Except for sinuses and minor periodontal problems, I too have been blessed with good health (other than Garrod Pads and Ledderhose). I'm curious about the DNA precursor since genetic breakthroughs and findings of diseases are in the news regularly. I doubt if Dupuytren research is high on the list of most scientists but hopefully, after the 'major' diseases have been analyzed, someone will take an interest in our affliction and hopefully, whether in our lifetimes' or not, a cure will be found. Is there anyone out there who has the offshoots of Dupuytren's (Garrod Pads, Ledderhose) without the actual contraction of the ring and pinky fingers? The more I read about this disease, along with my personal experience, the more interested I become. Dupuytrens seems to have a mind of its own and affects individuals differently without seemingly rhyme or reason. Thanks.
|
|
|
|
1 2
|
1 2
|