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Collagenase sounds great, let~sq~s do it.
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06/03/2006 23:04
jh

not registered

06/03/2006 23:04
jh

not registered

Phase 3 trials

They've been announcing postponements of this trial every year since at least 2001. In my opinion there is no serious intent to complete these trials and in a nutshell, this is never going to happen.



06/04/2006 23:14
JD

not registered

06/04/2006 23:14
JD

not registered

Phase 3 trials

Wont they loose their patent soon if the trials are not completed? If they do what would happen then? Can another company pick it up and proceed with the trials and then market the drug. I dont know if this is true but if it is it may make them proceed with the trials.


JD

06/04/2006 23:35
Cyclone

not registered

06/04/2006 23:35
Cyclone

not registered

Collagenase

JD

as I understand these are trials for FDA approval.
The patent rights are another matter altogether. Once the rights are secured they last for a very long time.

06/05/2006 23:25
Randy H.

not registered

06/05/2006 23:25
Randy H.

not registered

What is the Point?

Jim,

Compared to the fact that BioS has unwittingly provided the means by which the small club of CHS in the US will soon be brought to their senses regarding NA, it should matter *not* to any of us that your take on their intentions may in fact be correct. Perhaps they let this Forum continue only as a pretense. Reguardless, should you or I need additional medical intervention for Dups, the *only* reason we will not immediately face Open Surgery is at their expense, and their expense alone.

Should Collegenase ever come to market, I see that simply as a Bonus for what they have already allowed to be achieved. While proper to question their BioS Spin, should we loose our appreciation of what they have already unwittingly given to us all? I say don't don't kick this Gift Horse in the mouth so quickly.

Give it about two more years, after which we can all have NA within driving distance :-)

06/05/2006 23:43
jimh 
06/05/2006 23:43
jimh 
Collegenase

Although NA is obviously rapidly eroding the market for collagenase, maybe collagenase could do a better job on PIP joints, which are a problem for me.

Auxilium may be serious about getting approval for collagenase for Peyronie's. If that happens it could conceiveably be used "off-label" for Dupuytren's - I think - IF the hand surgeons would get interested, which is another question.

06/05/2006 23:31
JD

not registered

06/05/2006 23:31
JD

not registered

Collegenase

While NA is certainly an option that should be your first line of defense in the battle against Dups, I think that collagenase holds great promise. This drug if it really disolves the bad tissue and does not damage surrounding tissue may keep the disease under control. It may be able to disolve the nodules, and if it can do this then what happens to the cords? It also may reduce the likelyhood of reacurance.We need as much options as posible until the disease is someday cured. But I agree the companys that could help so many seem to only disapoint us year in and year out. Thanks to DR Eaton and others out their we now have an option that is able to help avoid surgery in many cases.




06/14/2006 23:58
Baron

not registered

06/14/2006 23:58
Baron

not registered

Collegenase

Collegenase is a farce! It will not be available in our lifetimes. By then more advanced treatments will be available. Time and medicale advancements march on. Forget about collegene. Embrace NA for now.

06/14/2006 23:22
Randy H.

not registered

06/14/2006 23:22
Randy H.

not registered

For What it is worth

Well, now that NA is no longer seems to be controversial on this site I suppose we need *something* to get all excited about. The latest is the idea that our Host's product (Collagenase), and the whole reason this Forum exists, is an economic sham. That the product actually works has been confirmed by FDA Phase II clinical trials. That it isn't moving forward is causing some to question BioS motives.

For what it's worth, here is the history of posts about BioSpecifics as made at Global Province, which is an online investors website. As for as I know it's the best source of info about our host available.

http://www.globalprovince.com/BSTC.htm#82

Eaton has included an MD to discuss Collagenase treatment in his presentation in September. Since BioS ownes the patient on the stuff, it appears that Eaton has not lost all hope in our Sponsor. Where else can you get Collagenase?

06/14/2006 23:43
jim h

not registered

06/14/2006 23:43
jim h

not registered

The hook is set

Randy, thanks for that very interesting link. Unfortunately I think it only reinforces the idea that Biospecifics isn't entirely sincere about making this drug available. That link contains P.R. announcements going all the way back to 1996 which have been essentially repeated every year since then.

In the spring, the trials are scheduled to begin in the fall. In the fall, they've been delayed until spring. Big money is raised, big money is spent, money runs out. They were apparently doing Phase II work in 96 and earlier.

At some point you have to conclude, this is just not going to happen and some sort of investment game is being played here.

06/14/2006 23:34
Randy H.

not registered

06/14/2006 23:34
Randy H.

not registered

The hook is set

Well Jim, there I was, right in the doctor's office at UCLA who had been negotiating with BioS to earlier that day to run one of the CA sites for Phase III. He told me he was hopeful that they could come to terms. Obviously they didn't. But what I wonder is why go through the motions to negotiate with the guys to run Phase III when you never even intend to go through with it?

Oh I get it. First you invent the stuff. Then you get a patent. Then you invest a bunch of money to go through Phase I and Phase II. Then you set up four sites for Phase III and get all the doctors that are going to participate on the same page. Everything is in place except the money. You do all this just to set up the Con. The hook is set. The trap is baited.

Now, looking to all the World like you are for real and on the verge of a financial and medical breakthrough, you suck in as many investor dollars as you can and just spend it on yourself. Hopefully no one will notice where all the money actually went, since it certainly didn't go to the clinics all ready to go and just waiting for the cash.

It all make sense to me now. Elaborate yes. But effective.

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