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10/13/2004 23:44
neilnot registered
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10/13/2004 23:44
neilnot registered
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treatment
has anyone heard about a "supposed Possible" treatment using Botox injections or is this a another hopeless rumor. It was supposed to be on TV last week.
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10/13/2004 23:28
Francesnot registered
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10/13/2004 23:28
Francesnot registered
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Google search
I searched 'botox' and 'dupuytren contracture' together and didn't find any such info....even looked under the website of clinical trials...
Thanks for posting though...
Frances
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10/14/2004 23:58
The Other Briannot registered
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10/14/2004 23:58
The Other Briannot registered
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Botox
Isn't Botox the toxin from Clostridium botulinum (the
causative agent for "lock-jaw.") Someone may have made the
association between "Collagenase" (clostridium toxin) and
c. botulinum and reported the Biospecific trials as Botox
rather than "Collagenase." I am not a microbiologist and cannot remember the exact strain of clostridium organism involved. I do not think Biospecific uses the same strain
as the Botox variety. Undoubtedly, someone else on this board will know. Gangrene occurs when clostridium spores
contaminate wounds (dirt, soil in cuts.) The Biospecific
appraoch is a controlled version of the process IMO. That
is why trials are conducted to evaluate results and safety.
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10/24/2004 23:09
Keith Denkler MDnot registered
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10/24/2004 23:09
Keith Denkler MDnot registered
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Botox
Clostridium tetani (tetanus) causes lock-jaw. Clostridium botulani causes botulism, a severe type of food poisoning.
Botox has been used medically for multiple musculoskeletal disorders such as tennis elbow and whiplash. I have not idea if Botox would work on the contractile myofibroblasts that cause the contractures in Dupuytren's. It is a thought. However, I don't believe it would relax a fixed contracture. Possibly it could have some use in prevention or maybe for a Dupuytren's flare.
Keith Denkler MD
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11/04/2004 23:09
Denisenot registered
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11/04/2004 23:09
Denisenot registered
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Dupuytren with Botox.
Hi! I saw the same news show and have been surfing for two days trying to find the doctor that treats
Dupuytren with Botox. Please let me know if you have any luck and I will do the same.
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11/04/2004 23:30
The other Brian (Bosox fan)not registered
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11/04/2004 23:30
The other Brian (Bosox fan)not registered
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Clostridium web site
Sorry Denise, I cannot answer the question. I am
re-posting a previous addendum to my Clostridium post.
I connected it to the wrong thread to correct an error
and decided it was unimportant. If others search as you
did, they may find the subject informative. So, here it is
again; this time in the correct thread, albeit wrong place.
Mea culpa, mea culpa, mea maxima culpa!http://textbookofbacteriology.net/clostridia.html
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06/30/2006 23:21
Lyn kienholznot registered
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06/30/2006 23:21
Lyn kienholznot registered
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botox and dupuytrens~dq~
Dr. Denkler or anybody,
The posting in 2004 regarding botox and dupuytrens came to no conclusions. Is there anything new on this subject? Two pianist
friends have botox treatments for Dystonia, but don't know anything about the Dupuytrens connection. Would appreciate any news.
Lyn
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07/01/2006 23:01
Botoxnot registered
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07/01/2006 23:01
Botoxnot registered
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Botox and Dupuytren~sq~s
I have injected two patients with Dupuytren's nodules with Botox. One had a dramatic imporvement in reduction in pain and itcing. The other had no change.
Botox can releive pain and relax the myofibroblasts that are in Dupuytren's, but I don't think it will relieve contracture. I don't have a speciifc defined role for it yet. Possibly for reactive, painful, itchy nodues although I generally use Kenalog for that. I will keep trying it on occasion.
Keith
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