May I ask your age and whether or not you have tried RT?

Hi
I am aussie 36 year old now
Started getting dup in LH when 28 just on ring finger
Few years later on right hand affecting ring and index finger
The last year or two am developing garrot pads on every finger except thumbs. Lots of pain particularly first thing in morning can fully close fists both hands
Tried radiation therapy a few years ago didnt seem to do anything
Noticed when i went to a keto diet for 3 weeks my inflammation and pain dropped signficantly but i just couldnt keep diet going as i exercise a lot like running and was feeling like i had no energy. Back to normal diet. Have gone to compoumd chemist im canberra using 15%verapamil eith activemax as the transdermal soln and plan to apply 2-3 times daily.
No peyronies and nothing in my feet yet touch wood as my hands are bad enough.
Will post results as i go
Pharmacy charged $135 for making up 100 grams

I have rubbed it in once now goes on pretty easily a little itch and hands feel a little chalky so i hope the verapamil is going in.

I notice coffee, alcohol, lack of sleep, rock climbing, and weight bearing or hand clenching causes my hands to tingle and my gut feel says a very healthy diet and lifestyle could slow progression.

Miss my climbing

Transdermal verapamil cream can be effective in the treatment of Ledderhose Disease under the right circumstances.

1) Consider the ability for any topical medication to be able to penetrate the tissue to be treated. The larger the lesion and the “rounder” the lesion, the less the ratio of surface area to interior volume. Under such circumstances the penetration of Verapamil or any topical medication to the target tissue is limited. We see significantly more success in smaller, flatter lesions or lesion that have been reduced in size with fibrinolytic enzymes. The flatter the lesion, the higher the surface area to interior volume thus more of the medication penetrates.

2) Consider prior treatment history. Verapamil, in theory, works by inducement of endogenous fibrinolytic enzymes production. Enzymes act on specific and viable substrates. It has been my experience that prior radiation therapy results in tissue changes leading to significantly reduced activity of fibrinolytic enzymes both exogenous (injected) and endogenous (via stimulation from topical verapamil)

I have heard this treatment was more effective for those who started in early, who had newer, smaller nodules.
I tried Verapamil on several nodules on my foot for more than a year. I did not experience any improvemnt...no softening, no reduction in size or pain. I will say, I started this several years and two surgeries into this disease. I have significant scar tissue and fairly large nodules.