I have been taking verapamil orally for about 10 years for prevention of migraines. If the cream is supposed to help Ledderhose, I wonder why the oral medication does not have any effect at all on the Ledderhose nodules.

By the way, the nodules on my foot shrink and grow (back and forth) for no apparent reason. I think it is inflammation coming and going, with the original nodules probably staying more or less stable. However, this winter, I developed a new nodule on each foot.

As far as I know my diet has not changed, but I too often suspect food intolerances of some kind as causing the inflammation. I do water aerobics in a chlorinated swimming pool in summer. This seems to increase the inflammation around the nodules each summer, but the new nodules (without inflammation) appeared in winter.

Not so far,I was really hoping that Verapamil would work i feel discouraged.
So far I just used Voltaren cream with partial results

Hello,
Just wanted to update. The verapamil did nothing for me. It did however, make my feet so slippery that I feared I would fall, so discontinued as I am on a breast cancer drug that causes brittle bones. It just wasn't worth it to me, and really, where is the data....

Re: Started verapamil gel this week- PD Labs
For those of you suffering from Ledderhose nodules...has anyone considered radiation therapy?

I had two large nodules in my left foot treated with RT by Dr. Tripuraneni in Scripps La Jolla, CA. in Nov. 09.... the nodules are still there, but they are definitely smaller and softer.... at least that's my personal experience.

I also use custom made orthodics. The nodules of my foot never bothered me when walking, I did the RT to hopefully prevent the nodules from continuing to grow.
Hi Luba--Do you know if Dr. Tripuraneni has any data on treating with RT that I can access on the web? I'd like to show data to a local doc. Thank you!