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Radiation induced cancer - other forms of conservative treatment?
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04/17/2024 12:20
Marius 
04/17/2024 12:20
Marius 
Radiation induced cancer - other forms of conservative treatment?

Let me introduce myself. I am a 22-year old young man from Denmark who suffers from Plantar Fibromatosis/Ledderhose disease. I have suffered from this condition in more than 10 years. During this period the condition has become more and more severe. By now it is a major obstacle preventing me from living my every-day life. I have been through the Danish health-care system and no-one has offered me treatment. Apparently there is a lack of knowledge and experience with regard to ledderhose and related diseases in Denmark. The latest doctor whom I visited told that there is substantiel risk of cancer when receiving RT. I am not sure what to believe, partly because I myself could not find evidence that support my doctor´s opinion. Therefore I am reaching out to you. Are some of you familiar with researches that revolve about this topic?

Furthermore, which other treatment options have you (ledderhose patients) looked into or received? I have read about collagenase Clostridium histolyticum - which i suppose is used synonymously with the name Xiapex/Xiaflex? Do any of you guys have experience with that treatment?

Best, Marius

04/17/2024 16:55
wach 

Administrator

04/17/2024 16:55
wach 

Administrator

Re: Radiation induced cancer - other forms of conservative treatment?

Hi Marius,

indeed, the risk of cancer is higher the younger you are when treated with radiotherapy. The risk to develop cancer with radiotherapy of Dupuytren's or Ledderhose is estimated on https://www.dupuytren-online.info/downlo...ren_Disease.pdf . You can see that the risk to develop cancer at the age of 25 is about 10x higher than when treated at the age of 75. That's not really surprising because young people live much longer and therefore have a higher risk for developing cancer.

Yet the risk to develop cancer due to this radiotherapy is generally relatively low because of the low dose applied. For general information on radiotherapy of Ledderhose you might have a look at https://www.dupuytren-online.info/radiation_therapy.html .

If you are interested in how satisfied Ledderhose patients were with various types of treatment, have a look at the result of a survey with 1,000 Ledderhose patients participating: https://www.dupuytren-online.info/patient_survey.html .

Wolfgang

04/17/2024 17:13
Marius 
04/17/2024 17:13
Marius 
Re: Radiation induced cancer - other forms of conservative treatment?

Thank you very much for the answer! I have read some promising things about radiation therapy on this forum and recognized the name of Dr. seegenschmiedt in different posts. I have therefore scheduled an appointment with a clinic called Strahlentherapie Duisburg - a clinic to which doctor seegenschmiedt is associated. With the increased risk of cancer, (i´m 22) in mind, I am wondering if it would be better if i began with vitrase or xiapex injections? I have seen people on this forum mention Dr. Davis from San Antonio when it comes to vitrase/hyaluronidase injections. But I find it difficult to source evidence with regard to vitrase/hyaluronidase injections. To your mind, would it be better if I tried vitrase treatment before RT?

Best Regards Marius

04/17/2024 19:51
wach 

Administrator

04/17/2024 19:51
wach 

Administrator

Re: Radiation induced cancer - other forms of conservative treatment?

"I find it difficult to source evidence with regard to vitrase/hyaluronidase injections." Me too ... I never heard that vitrase would help curing Dupuytren's or Ledderhose. -- To my knowledge, trials to use Xiaflex for Ledderhose have been stopped. Probably the results were not very promising. And currently, as the vendot stopped selling Xiaflex in Europe, it would have to be imported, making it prohibitively expensive.

BTW, Prof. Seegenschmiedt is offering video consultation. Maybe that would be an easy start?

04/18/2024 06:18
spanishbuddha 

Administrator

04/18/2024 06:18
spanishbuddha 

Administrator

Re: Radiation induced cancer - other forms of conservative treatment?

wach:
"I find it difficult to source evidence with regard to vitrase/hyaluronidase injections." Me too ... I never heard that vitrase would help curing Dupuytren's or Ledderhose. -- To my knowledge, trials to use Xiaflex for Ledderhose have been stopped. Probably the results were not very promising. And currently, as the vendot stopped selling Xiaflex in Europe, it would have to be imported, making it prohibitively expensive.

BTW, Prof. Seegenschmiedt is offering video consultation. Maybe that would be an easy start?
Dr Davis moderates a FB group dedicated to the hyaluronidase injections and the topical application of verapamil. There is a lot of discussion there on its efficacy or otherwise. Some people report amazing results and others disappointment. I believe there are some 'papers' there in the files section.

04/18/2024 08:20
wach 

Administrator

04/18/2024 08:20
wach 

Administrator

Re: Radiation induced cancer - other forms of conservative treatment?

Sounds more like a business supporting activity, some sort of FB marketing?

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