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Forum for Dupuytren's and Ledderhose 
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    12/29/2006 00:34
    kdenkler 
    12/29/2006 00:34
    kdenkler      		Medical Publications

    Here is a link of full-text articles on Dupuytren's available from the national library of medicine "PUBMED Central"
    Articles can be old, but they are full text and not just summaries.

    Link below

    http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Search&;db=pmc&term=dupuytren+s&tool=fuzzy&ot=Dupuyten%27s
    12/29/2006 00:36
    kdenkler 
    12/29/2006 00:36
    kdenkler      		Re: Medical Publications

    Copy and paste entire link into browser.
    Highlighted link does not work

    http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=pmc&;;cmd=search&term=dupuytren's
    01/03/2007 00:33
    jim_h 
    01/03/2007 00:33
    jim_h      		Re: Medical Publications

    Thanks for the link.

    I can't help but comment that my reaction, after scanning that list of papers, is that with the exception of needle aponevrotomy, there's been virtually no progress in 40 years, from the point of view of the patient.

    Surgical techniques have no doubt improved, but the typical end result of surgery is about the same. There's been research into the genetics and biochemistry - many papers with words like "promising" and "interesting" - but no useful treatment has resulted and there's no indication of any follow-on work in progress.

    One can read numerous studies on genetic links, biochemical precursors, cellular changes, and learn about myelofibroblasts, TGF, free radicals and antioxidants but at the end of the day, there's only one thing we can do in 2007 - go in with a sharp instrument and cut away at the bad tissue. Fortunately, in many cases that works reasonably well.


    Well there's still AA4500, I guess, which might see the light of day in 5 years if the stock market cooperates.
    01/17/2007 23:55
    kdenkler 
    01/17/2007 23:55
    kdenkler      		Re: Medical Publications

    Good point Jim H, I agree!
    I believe most hand surgeons are waiting for collagenase but till then sharp release is still the most common treatment. Usually by cutting out and now more frequently NA.
    Don't forget small knife release was very popular till just after Dupuyten's death till around the 20th century then radical surgeries became popular.
    I have Adams book from 1892 that extolls the virtues of subcutaneous release of Dupuyten's. NA is really a varient of his procedure albiet with needles instead of small knives.

    William Adams On the treatment of Dupuytren's contraction of the fingers, and on the obliteration of depressed cicatrices by subcutaneous operations. 1879. 2nd edition, 1892.

    The suprising reality is that complications from NA are less than with open surgery, which I presented at the ASSH meeting. This truth is even in face of the fact that NA is a blind procedure.

    I am grateful for this site and the moderators, and the lack of SPAM.
    Thanks
    Keith
    01/18/2007 09:39
    slyporks 
    01/18/2007 09:39
    slyporks 

    		Re: Medical Publications

    Study from Uppsala Sweden
    http://publications.uu.se/theses/abstrac...n=91-554-5262-0
    01/20/2007 15:47
    Bob_Branstetter 
    01/20/2007 15:47
    Bob_Branstetter      		Re: Medical Publications

    I would also like to thank Kdenkler for the link. It was interesting for me to look at some of the 38 papers that have been written by the surgeon who is treating me, Dr. Lynn D. Ketchum. While I wish that I had access to the complete text of all of the papers, I'm grateful for what is available. In addition to articles on Dermofasciectomy, I also found more information on Triamcinolone injections which I have had on done on my left hand.

    While I'm at it, I would also like to thank Wolfgang and Randy for making the old posts from the BioSpecifics Forum available to us on this forum. I had previously tried to wade my way through the Spam on the BioSpecifics site, but I was seldom able to find what I was looking for. I have now spent several hours going through the old Forum Archives and have found it to be a great addition to this forum. This site gets better every day.
    03/30/2007 12:54
    Wolfgang

    not registered
    03/30/2007 12:54
    Wolfgang

    not registered

    		 Free full articles

    I find below link useful to spot free full medical articles, not just abstracts:

    www.findarticles.com

    You can input your seach terms and additionally select "free articles only".

    Wolfgang
    03/30/2007 12:56
    wach 

    Administrator
    03/30/2007 12:56
    wach 

    Administrator

    		 issue with long links

    Unfortunately our forum software has a bug and can't process long links properly. We were assured that this will be fixed in the next release (as usual). Sorry about that!

    Wolfgang

    Quote:


    Copy and paste entire link into browser.
    Highlighted link does not work

    http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=pmc&;;cmd=search&term=dupuytren's
    10/24/2007 18:19
    kdenkler 
    10/24/2007 18:19
    kdenkler      		Re: Medical Publications

    Here is a nice open access article on Dupuytren's Surgery

    http://www.biomedcentral.com/1471-2474/8/60

    http://www.biomedcentral.com/content/pdf/1471-2474-8-60.pdf

    It is a large series review of 2919 operated fingers for Dupuytren's.
    Nerve damage rate with open surgery was 3.7%!

    No mention of needle aponeurotomy or radiation
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