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No family history
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06/22/21 19:13
Threeper 
06/22/21 19:13
Threeper 
No family history

No family history

Hi. I'm 36yo, male, caucasian with no family history of Dupytrens. Developed first bump near a year ago in palm of right hand under middle finger, below the top crease. When had ultrasound they told me nothing, though went back for biopsy they declined to do it and told me I have palmar fibrosis. Developed several more nodules since December either side of original below middle and little fingers. I saw a hand specialist who told me it looked like Dupytrens/palmar fibrosis (he wasn't term specific). Any way I was wondering how common this is without any family history (I know my parents, brothers, uncle, aunt and grandparents did not have it. I am half Swedish) And if I should investigate further as my lack of family history and young age left me not super confident in the diagnosis. The hand specialist mentioned biopsies potentially aggravating the condition so I wanted to know if one might be warranted. Appreciate any advice.

Edited 06/22/21 19:20

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06/22/21 20:38
wach 

Administrator

06/22/21 20:38
wach 

Administrator

Re: No family history

You are not alone, about half of the people with symptoms of Dupuytren's don't know anybody in their family who has Dupuytren's https://dupuytrens.org/dupuytren-facts-figures/ . In my case, I probably inherited it from my mother but I found out only accidentially that she had a small nodule in her palm. She never had talked about it and did not consider it worth mentioning.

I developed my first nodule at the age of 35, which is a little early compared to the average age of 46 for male, but if you look at the graph on https://www.dupuytren-online.info/patient_survey.html you see that quite a few people experience the onset of Dupuytren's much earlier. BTW, are you smoking or did you smoke? That might cause an early onset.

Wolfgang

06/22/21 23:11
Prof.Seegenschmiedt 
06/22/21 23:11
Prof.Seegenschmiedt 

MANY OTHER REASONS than FAMILY BACKGROUND

Threeper:
No family history

Hi. I'm 36yo, male, caucasian with no family history of Dupytrens. Developed first bump near a year ago in palm of right hand under middle finger, below the top crease. When had ultrasound they told me nothing, though went back for biopsy they declined to do it and told me I have palmar fibrosis. Developed several more nodules since December either side of original below middle and little fingers. I saw a hand specialist who told me it looked like Dupytrens / palmar fibrosis (he wasn't term specific). Any way I was wondering how common this is without any family history (I know my parents, brothers, uncle, aunt and grandparents did not have it. I am half Swedish) And if I should investigate further as my lack of family history and young age left me not super confident in the diagnosis. The hand specialist mentioned biopsies potentially aggravating the condition so I wanted to know if one might be warranted. Appreciate any advice.

Dear "Threeper"

Besides "GENETIC RISKS" other factors can play a role :

>PREDISPOSING DISORDERS, like Diabetes, Thyroid Disease, Liver Disease; some habits like drinking alcohol and smoke (Nicotine connsumption); possible vasoconstrictive medications or pathomechanisms like RAYNAUD SYNDROME

>CHRONIC MECHANIC STRESS like craftsmen working with jack hammers

> Other professional or leisure activities inducing micro-traumata or

> hypoxic conditions in a long-term healing process after bone fracture or soft tissue trauma

When looking at your photograph I also detect 2 cords in conjunction with the two nodules. This needs to be carefully examined. You should also explore your foot soles for a possible Ledderhose Disease.

OVERALL EARLY USE of RADIOTHERAPY in a stage which could still be defined as a favourable STAGE N should be considered on your side. If you like I could offer you a VIDEO CONSULTATION with specific functional testing to assure a possible decision for either "WAIT & SEE" strategy or "EARLY RADIOTHERAPY"

You could reach out using the following E-mail: prof.seegenschmiedt@gmail.com

Edited 06/22/21 23:13

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+Dupuytren - Basic Documentation_Graphics_08-2020_English.pdf +Dupuytren - Basic Documentation_Graphics_08-2020_English.pdf (9x)

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06/23/21 08:32
Threeper 
06/23/21 08:32
Threeper 
Re: No family history

Thanks for the responses. Never smoked, no diabetes or hand injuries. Use to drink coke regularly, also previously was vitamin d deficient. The hand specialist seemed dismissive of non genetic factors. Also I don't feel any cords, I think it is just nodules at this point.

10/02/21 10:50
Threeper 
10/02/21 10:50
Threeper 
Re: No family history

How large do nodules get? The one under my middle finger is around 1.8cm by 0.9cm. Can't find any information on this.

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10/02/21 11:07
spanishbuddha 

Administrator

10/02/21 11:07
spanishbuddha 

Administrator

Re: No family history

Threeper:
How large do nodules get? The one under my middle finger is around 1.8cm by 0.9cm. Can't find any information on this.
One of my hands looks a bit like yours, and has stayed that way for years after RT. The other one started out like that too, but the larger nodule slowly but surely developed into a cord reaching up into the finger. The next phase, if it develops further, likely would be nodule 'fattening' or skin pitting or new nodules or cord development; along with soreness, tightening, itching, tingling, aching, that might indicate it's progressing?

Edited 10/02/21 11:16

10/03/21 01:42
Prof.Seegenschmiedt 
10/03/21 01:42
Prof.Seegenschmiedt 

Re: No family history

Threeper:
How large do nodules get? The one under my middle finger is around 1.8cm by 0.9cm. Can't find any information on this.


Dear Threeper,

Having treated about 2.500 patients with radiotherapy and performed about 100 videoconsultations since March 2019 I would dare to analyse your hand just from the "medium quality photographs" as much more developed than just a simple early NODULAR STAGE - from my perspective you have also signs of CORDS a d pobably MORE NODULES in digits D3, D4 and D5.
Much more details are possible to detect in a video examination ...

I am sending you the findings from your photograph and three sketches "HOW NODULES & CORDS TYPICALLY DEVELOP"

Best regards, Prof. Seegenschmiedt (E-mail: prof.seegenschmiedt@gmail.com)

With gratitude for all affected patients & m simple early edical colleagues who help to advance patient care ...

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InkedTHreeper_Dup-Forum_nodules-plus-cords1_Left-Hand.pdf InkedTHreeper_Dup-Forum_nodules-plus-cords1_Left-Hand.pdf (16x)

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10/05/21 12:53
Threeper 
10/05/21 12:53
Threeper 
Re: No family history

Ok thanks for responses. Feeling around there is a possible cord associated with the left nodule though it could just be the tendon I’m feeling. I had one last question that has been bothering me. I likely was very vitamin d deficient when the nodules appeared (like 1/10th recommended levels). The association of vitamin d deficiency and cancer has made me a bit paranoid regarding the diagnosis of my hand. Is there any association of vitamin d deficiency and Dupytrens?

10/05/21 13:34
spanishbuddha 

Administrator

10/05/21 13:34
spanishbuddha 

Administrator

Re: No family history

Threeper:
Ok thanks for responses. Feeling around there is a possible cord associated with the left nodule though it could just be the tendon I’m feeling. I had one last question that has been bothering me. I likely was very vitamin d deficient when the nodules appeared (like 1/10th recommended levels). The association of vitamin d deficiency and cancer has made me a bit paranoid regarding the diagnosis of my hand. Is there any association of vitamin d deficiency and Dupytrens?
I have not heard of a proven link between Vitamin D deficiency as a factor in DD. It's one of the to be investigated areas on the DRG https://dupuytrens.org/unexplored-frontiers/. But there is at least one interesting paper https://pubmed.ncbi.nlm.nih.gov/29857907/.

Edited 10/05/21 13:37

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